Comprehensive lung injury pathology induced by mTOR inhibitors

Molecular Targets in Oncology[Abstract] Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibro-proliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall cascade hypothesis of interstitial lung diseases that represents a common, partly underlying synergism among them as well as the lung pathogenesis side effects of mammalian target of rapamycin inhibitors

Toward the integration of monitoring in the orchestration of across spaces learning situations

Technologies such as augmented Reality (AR), 3D Virtual Worlds (3DVWs) and mobile phones are extending education to other spaces beyond the classroom or the Virtual Learning Environments (VLEs). However, the richness of across-spaces learning situations that could be conducted in all these spaces is hampered by the difficulties (encompassed under the “orchestration” metaphor) that teachers face to carry them out. Monitoring can help in such orchestration, and it has been highly explored in face-to-face and blended learning. Nevertheless, in ubiquitous environments it is usually limited to activities taking place in a specific type of space (e.g., outdoors). In this paper we propose an orchestration system which supports the monitoring of learning situations that may involve web, AR-enabled physical and 3DVW spaces. The proposal was evaluated in three authentic studies, in which a prototype of the system provided monitoring through a web dashboard, an AR app, and a Virtual Globe